CFS Researchers and research direction Paul van meerendonk
Biologisch Medisch Centrum Epe

Deze site is opgericht door een zeer tevreden cliŽnt van het Biologisch Medisch Centrum

Biologisch Medisch Centrum
Behandeling CVS/ME
ATP energie
Vitamine D
Dr Teitelbaum
Dr Meirleir
Dr Cheney
Arts Paul van Meerendonk

ADP-ATP efficiency
Cvs en fibromyalgie
valganciclovir
CVS ME aantoonbaar
CVS legitiem
Research direction
CT

Virus en DNA
Dr Kerr
esme
Dr Chia
Zware metalen
Cadmium


 


 

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Dr Kenny de Meirleir   bacterial   viral    gastrointestinal symptoms
80% to 90% ME/CFS patients compromised by bacterial and/or viral pathogen  
Epstein-Barr Virus and HHV-6    /  intestinal bacteria /  probiotics  /  fructose malabsorption  /  heavy metals  /  Gluten intolerance at different levels
 
Dr Paul Cheney         viral   pathogen   toxic   inherited   video
For more than 25 years, Dr. Cheney has been a pioneering clinical researcher in the field of ME/CFS and has been an internationally recognized authority on the subject of ME/CFS.
He has published numerous articles and lectured around the world on ME/CFS and is author/co-author of numerous publications and scientific presentations about ME/CFS.


Dr. Jonathan Kerr        viral gene expression
Development of a diagnostic test , analysis of human and viral gene expression in the white blood cells, and clinical trials of immunomodulatory drugs. He has recently published research identifying distinct subtypes in patients with ME/CFS.


Dr. John Chia         70 types of entero viruses
Chronic fatigue syndrome associated with chronic enterovirus infection of the stomach  on the role of enteroviruses in the aetiolgy of ME/CFS Ė an area which has been implicated as one of the causes by a number of studies. There are more than 70 different types of enteroviruses that can affect the central nervous system, heart and muscles, all of which is consistent with the symptoms of ME/CFS.  By analyzing samples of stomach tissue from 165 patients with CFS, Dr. Chia's team discovered that 82% of these individuals had high levels of enteroviruses in their digestive systems. Dr Chia's research may result in the development of antiviral drugs to treat the debilitating symptoms of ME/CFS.

Dr Nancy Klimas         immune, autonomic and neuroendocrine interactions
The University of Miami CFS Research Center is exploring interactions between the immune, autonomic and neuroendocrine.

Professor Nora Chapman         effects of viruses upon cell function.
She and her associates have demonstrated that selection of defective enterovirus in heart and other tissues leads to persistent infections despite active antiviral immune responses.
Presently studying the mode of selection of these viruses and the effects of replication of these viruses upon infected cell function.
 
Annette Whittemore - Dr Daniel Peterson       human herpesvirus 6 (HHV-6)


Prof Garth Nicholson             mycoplasma infections
Human Herpes Virus-6 (HHV-6) and Cytomeglovirus (CMV).

Dr. Donald Lewis         
immunological dysfunction
CFS develops from a virus in most people


Jose Montoya  
    human herpes viruses

Dr William Weir      viral  bacterial  injuries
EB virus infection, salmonella, tetanus injections or whiplash injuries

Professor Andrew Lloyd   Immunology -Virology -Infectious Diseases -Inflammation -Pathology
Anti viral Immunity -Cytokines -Chemokines -Post infective fatigue states -Hepatitis C



However, certain continuity was given by the lectures of de Meirleir, Kerr,  Peterson, Nicholson, and Chia, which are tied together by several threads. These include the search for diagnostic markers, the treatment of gut dysbiosis through diet and probiotics, and the search for complicating pathogens, and their treatment



 


 

Neuropathology of post-infectious chronic fatigue syndrome

Journal of the Neurological Sciences 2009 (S60-S61)

Cader S., O'Donovan D.G., Shepherd C., Chaudhuri A.

Abstract

Purpose: The pathogenesis of severe and relapsing chronic fatigue after
viral or bacterial infection is unknown. Many patients with post-infectious
chronic fatigue, which is classified as a neurological disease (G93.3,
ICD-10 classification), become disabled and do not recover fully despite
symptomatic and rehabilitative therapy.

Method: We report here the histopathological changes in the dorsal root
ganglia of three female patients with a diagnosis of chronic fatigue
syndrome. All three patients were seen by their local physicians and
specialists who had excluded alternative medical cause for their symptoms of
disabling fatigue and chronic pain. Due to the nature of death, a full
autopsy examination was carried out in each of these cases.

Results: The most remarkable and consistent abnormality was the presence of
active inflammation with T8 lymphocytic infiltration in the dorsal root
ganglion of one patient and evidence of past inflammation (nodules of
Nageotte) in two patients.

Conclusion: Dorsal root ganglion is the gateway for sensory information
reaching the central nervous system. Based on the histopathological changes
observed in three cases, we propose that inflammation of the dorsal root
ganglia
may play a key role in the pathogenesis of post-infectious chronic
fatigue. Abnormal processing of sensory information secondary to dorsal root
ganglionitis
could potentially contribute to fatigue due to higher perceived
effort and pain because of reduced sensory threshold
. This may lead to new
treatment options in a group of patients that currently present a
significant challenge to neurologists.